Synthesis and Study of Acetylenic Amines Derivatives from p-Aminophenol

Abstract

New acetylenic amines derivatives from p-aminophenol have been synthesized
through Mannich reaction which involved reaction of
p-acetamidophenyl propargyl ether and p-phthalimidophenyl propargyl ether with
paraformaldehyde and secondary amines. Some of the synthesized acetylenic amines
passed through alkaline hydrolysis to release free amine group which was allowed to be
reacted with aldehyde or ketone to produce shiff bases. The synthesized compounds
were investigated by physical and spectroscopic methods.