Spectrophotometric Determination of chlorpromazine Hydrochloride in Pharmaceutical Preparations by Using Oxidative coupling reaction

Abstract

A simple, rapid and sensitive spectrophotometric method for the determination of
microgram amounts of chlorpromazine Hydrochloride drug in aqueous solution is
described. The method is based on the Oxidative coupling reaction between
chlorpromazine hydrochloride and para methoxy aniline in the presence of sodium
periodate and Sulfuric acid to form an intense red -Violet colored product with
maximum absorption at 546 nm. Beer’s law is obeyed over the concentration range
of( 0.5 – 11.2) ppm with molar absorptivity of 6.398x104 l.mol-1.cm-1 and Sandell`s
sensitivity of 0.005
μg.cm-2 . The method does not resort to temperature control or to solvent extraction.
The optimum conditions for all colour development are described and the proposed
method has been successfully applied for the determination of chlorpromazine
hydrochloride in bulk drug and pharmaceutical Preparations(Largactil drug). The
common excipients and additives did not interfere in this method.