Polycondensation of Allopurinol with EDTA and CDTA as Chelation Polymers for Transition Metals

Abstract

Chelation polymers for transition metals were prepared by copolymerization of
Allopurinol, a known drug for the treatment of gout and hyperuricaemia, with
ethylendiaminetetraacetic acid (EDTA) or cyclohexyldiaminetetraacetic acid (CDTA).
The prepared condensed polymers were characterized by using the following
spectrometric techniques: UV-visible, 1H-NMR and FT-IR. Their thermal behavior
were studied by using thermogravimetric analysis, The intrinsic viscosities in DMF
were calculated, and their % swelling in water was measured at 30°C.Their softening
point were measured, Also the carboxylic acid functional groups content were
measured by acid-base titration.
When they were polymerized with as a diamine drug compound; these new drug
polymers were modified with metal ions as good ligand, which could be complexes
with many poison metal ions.