Study of some biochemical changes in serum of patients with chronic renal failure

Abstract

The present study is concerned with the investigation of the activity of the
folling enzymes adenosine deaminase (ADA), `5-nucleatidase (`5-NT) and amylase.
The concentration of selenium (Se), iron (Fe), sodium (Na), potassium (K),
peroxynitrite and vitamin A have been measured in blood serum from patients with
chronic renal failure (CRF) undergoing hemodialysis .
Thirty-five patients with CRF before and after having hemodialysis and 62
healthy controls were included in this study.
The results showed a significant decreased in serum ADA activity of CRF
patients while `5-NT and amylase activities were significantly increase in these
patients when compared with blood serum from normal individuals. The
concentration of Se, Fe, Na and vitamin A were significantly decreased while
peroxynitrite was significantly increased. Potassium was increased, but the increase
was statistically insignificant. In a comparative study in pre-and post hemodialysis
cases, serum `5-NT activity and Na concentration in post hemodialysis patients were
significantly decreased but the ADA activity and Fe concentration were significantly
increased than those in the pre hemodialysis patients. There was no significantly
difference in the serum activity of amylase and in the concentration of Se, K,
peroxynitrate and vitamin A. In conclusion, hemodialysis patients exhibit some
biochemical changes before and after the dialysis when compared with control group.