Effect of Vitamin B1 2 on the Activity of Inhibited AChE

Abstract

Human serum AChE activity is measured in vitro using modified
Ellman method and shows a wide range between (4.925-8.755)
μmole/3min/ml. The activity in men was higher than in women. The
possible medical importance of Vitamin B12 as a remover of the effects of
poisonous and inhibiting compounds of AChE as possible substitute of
Atropine was tested, the results showed that Vitamin B12 behaved as a
reactivator, and the values of reactivation of both of Vitamin B12 and
Atropine on the activity of'inhibited AChE by heterocyclic compounds
sometimes appear approximately equal, these results lead to the
conclusion that, it is possible to use Vitamin B12 instead of Atropine in
treatment of poisoning caused by these types of inhibitors. Mechanism
of action of Vitamin B12 as reactivator was proposed.