Effect of Nioxim on the Activity of Inhibited AChE

Abstract

This study is designed to show the effects of Nioxim on the activity of
inhibited AChE by heterocyclic compounds in sera. The results obtained
showed that both Oxime causes decrease in percentage of inhibit ion. The
mechanism of action of the Oxime as reactivators to inhibited AChE activity
were suggested which attributed to the ability of this compound to attack the
thion group of the inhibited enzyme (enzyme-inhibitor complex) by the
nucleophilic oxygen atom and then liberate the free enzyme.