New Approach for the online determination of Paracetamol using merging zone-continuous flow injection analysis via home made photometric based on 704 nm LED and a photo silicon minidetector

Abstract

A simple, rapid and sensitive spectrophotometric method for the
determination of paracetamol using merging zone-continuous flow injection analysis
technique via hexagonal flow cell and home made photometric based on 704 nm LED
and a photo silicon minidetector was studied. The method was based on the oxidation
of paracetamol by Fe(III) solution which leads to the formation of Fe(II) which in turn
, reacts with Potassium hexacyanoferrate(III) to form Prussian blue dye and
determination of this dye at 704 nm.Chemical and physical parameters of this system
were investigated. The analytical graph is ranged from (0.0 – 10 mmol.L-1) with a
limit of detection 2.0 nmol.L-1.The relative standard deviation was 0.08% for 6.0
mmol.L-1 paracetamol solution (n=8).The method was applied for the determination
of paracetamol in pharmaceutical formulations.