Synthesis of New Antipyrines

Abstract

Synthesis of 4-(amino acetyl acetate) antipyrine has been obtained through the
reaction of 4-amino antipyrine with ethyl bromo acetate, then converted to hydrazide
derivatives by using hydrazine hydrate. This hydrazide on treatment with various aldehydes
and ketones offered Schiff base derivatives. Oxadiazole derivatives have been also
synthesized by treatment of above acid hydrazide with CS2/KOH or p-chlorobenzoic acid in
the presence of POCl3.
The synthesized compounds were verified by their IR, UV spectra and C.H.N.
analysis data.