Electrical conductivity of the antibiotics amoxicillin, trimethoprim and isoniazid in a setting Mane and at different temperatures

Abstract

This research is the electrical Conductivity study for each of trimetheprim, amoxicillin
trihydrate and isoniazid in conductivity water at different temperatures (288.15-313.15)
Kelvin By using lee-Wheaton equation for symmetrical electrolytes (1:1), The conductivity parameters have been calculated. The equivalent conductivity at infinite dilution (Λ°). The
ion pair association constant (KA) and the mean distance values between ion (R) at the best
value of standard deviation (δΛ). It is found that the values of (Λ°) and (R) for each drug
increase with increasing temperature, while the values of KA are inversely proportional with
temperature. By comparing these values, They follow the sequence:
Λo : amoxicillin trihydrate < trimetheprim < ioniazed
KA : isoniazid < trimethoprim < amoxicillin trihydrate
R : ionized > trimethoprim > amoxicillin trihydrate
An accurate method for determination of these drugs by using conductometric titration
method with hydrochloric acid and sodium hydroxide have been found to be good and
sensitive comparing with (the standard addition and potentiometric titration methods) from
encyclopedia.