Synthesis and Characterization of Some New Spiroazetidine-2- one Derivatives

Abstract

The present work include the synthesis and characterization of spiro
azetidin-2-one which achieved and expected to have some biological activity . the
first step include the treatment of primary aromatic amine with primary aromatic
aldehydes in boiling ethanol to give schiff bases which reacted in the second step
with carboxylic acid ( 1,3-dithia-2-carboxylicacid )in the presence of triethylamine
with phosphorusoxychloride in dry dichloromethane under nitrogen atmosphere at
0°C. To give spiroazetidin-2- one.The new synthesized compound were identified by
melting points and UV,FT. IR, Mass, 1H NMR and 13C NMR spectrum.