Study of Creatine Kinase Activity and Antioxidants in Serum and white blood cells in induced Diabetic Rabbits

Abstract

This study was included 22 rabbits induced diabetes mellitus disease (DM) by
injection the alloxan under skin, and then evaluation the activity of creatine kinase
and antioxidants of blood serum and white blood cells (WBCs),(glutathione and, uric
acid) with lipid peroxidants (malondialdehyde).
Before starting the evaluation, it was prepared the (WBCs) and serum from the
rabbits 22 control.
The results of the study showed that there are significantly increased in level
of MDA (μmol/L) in serum of rabbits with DM 1.68 , 0.43 for (WBCs)
compared with controls 0.83 0.29, 0.77 0.26 in both serum and (WBCs),
respectively and significantly decreased in activity of creatine kinase in patients for
serum 80.6 IU/L compared with controls 105.5 IU/L (P 0.01) in both
serum and, (WBCs) also significantly decreased in the level of the glutathione and
uric acid in patients 16.3 , 144.6 mol/L compared with controls 26.7
, 240.3 mol/L , (P 0.01) in both serum and, (WBCs).
Finally, this study was not found significant differences between the levels of
serum and (WBCs) in each groups of rabbits for all the parameters studied (creatine
kinase, glutathione, uric acid and malondialdehyde