Spectrophotometric determination of Chlorpromazine Hydrochloride in Pharmaceutical preparations

Abstract

The present study includes analytical method for determination of the drug
Chlorpromazine Hydrochloride (CPH) in some Pharmaceuticals using Molecular
Absorption, in addition to investigating complexes obtained throughout. The analytical
data obtained throughout this study could be summaries as follows: The optimal
experimental condition for the chelate formation: (pH=1.8); concentration of Pd(II) (20
μg.ml-1); reaction time (8 minutes); aqueous -to- organic phases (5:3); extraction time of
complex (1.5 minute); Benzyl alcohol proved to be the best solvent for extraction of the
complex CPH-Pd(II) without interference. λmax= 459 nm metal -to-ligand (1:1); stability
constant of complex CPH-Pd(II) (6.93×108 M-1).
Analytical figures of merits for determination of CPH using the developed
procedure: Linear dynamic range (3-70)μg.ml-1; Corrolation coffecient (r= 0.9993),
Sandell Sensitivity (S=0.0452μg.cm-2) ; D.L (0.13 μg.ml-1); Erel.% (0.18%); RSD%
(3.74%), Recovery % (100.2±0.42)%. Direct and standard addition methods were applied
to both standards and specimens of pharmaceutical. Stability of complex was also
investigated. For optimization of experimental condition, the response surface method
(RSM) was applied and data obtained were found similar. This method has been applied
to determination CPH in the well-known pharmaceutical Epichlor.