Lipid Peroxidation in Iraqi Men Newly Diagnosed with Non – Insulin Dependent Diabetes Mellitus ( NIDDM)

Abstract

This study was designed to investigate Lipid profile pattern and Lipid peroxidation in 40 Iraqi men newly diagnosed with non – insulin dependent diabetes mellitus ( NIDDM) compared to 40 healthy non- diabetic control. The results showed that blood glucose and lipid parameters were significantly increased ( p < 0.01) with the exception of HDL-c, which was significantly decreased ( p < 0.01). On the other hand, a significant elevation in malonedialdehyde level and a decrease in glutathione content were observed in newly diagnosed NIDDM in comparison with controls.
These findings indicate that the increase in Lipid peroxidation and decline in antioxidant defences, may appear early in newly diagnosed NIDDM, before the development of secondary complications and might play an important role in initiation and progression of diabetic complications.