Synthesis and Biological study of N-Cysteine Derivatives Via a Schiff Base

Abstract

This work includes the synthesis of some derivatives of cysteine and the biological
activity was investigated. The aromatic Schiff base which prepared from aniline and
benzaldehyde was reacted with α-chloroacetic acid and with different acid halide in dry
benzene to give benzyl chloride (Compounds : 2, 3, 4, 6) which were reacted with L&DCysteine
to give N-α-N¯-cystylbenzyl-N-alkanilide. The last synthesized compounds were
identified by melting points, UV-Visible, IR and 1H-NMR spectrum. Thy were also tested
against E.coli, Staphyllococus aureus, Klebsilla spp., Streptococcus pyogen, Listeria
Moncytogen, Sallmonela typhi., Pseudoms aerugenosa and Brucella.