A New Keynote of β –Thalassemia Major Patients As Oxidative Stress Accompanying

Abstract

This study evaluated the total thiols group(-SH), total serum protein, albumin
concentration and vitamin E, as well as peroxynitrite in serum as a parameter of
peroxidative stress for patients with β– thalassemia major, transfusion dependent,
compared with healthy controls. We found that the levels of total thiols and total protein
are significant decreased, while the albumin concentration slightly decreased in patients
compared with controls where as the depletion of the vitamin E concentration in serum
of patients is accompanying the increasing of peroxynitrite levels. The results suggest
that the measurement of peroxidative product matched with evaluation of antioxidants,
may be a simple measure of iron toxicity in thalassemia.