Chemoselective Synthesis and Reactions of Some New Thiophthalimidines and 3-Ethoxythiophthalimidines

Abstract

A number of phthalimidines (6) and 3-ethoxyphthalimidines (3) were
synthesized by the reduction of the corresponding phthalimides under different
conditions. Treatment of the formers with diphosphorous pentasulfide (P2S5) in dry
dioxane afforded the thio derivatives (7) and (4) respectively. Reaction of (7) and (4)
with ethyl amine gave imines (8) and (5), respectively. Hydrolysis of the imines
restored the starting (6) and (3).
The structure of all compounds were identified by physical, chemical and
spectroscopic data.