Synthesis of 5H-Oxadiazoline Derivatives from Oxime Isatin

Abstract

A series of heterocyclic compounds 1,2,4-5H oxadiazol [4a-e,5a-c] derivatives were
prepared by the reaction of aldehyde and ketone with amidoxime in which the latter was
obtained from the reaction of corresponding nitrile with hydroxyl amine hydrochloride. The
prepared compounds were characterized by IR spectra.