Synthesis and antibacterial evaluation of Some Pyrano-1,3-- Oxazine Derivatives

Abstract

Some dipeptide amide and amino derivatives of 7-chloro-4,5-dioxopyrano
[3,4-e]-l,3-oxazine, compounds (2a-d) and (3a-e) respectively have been synthesized
and studied against five species of bacteria in vitro. A significant activity against
staph. Aureus and Bacelus Subtilis were observed by the above derivatives at
concentration ranging from (0.1-10 mg./ml.) and remarkable activity was exhibited by
2-(N-glycyl glycine amido)-7-chloro-4,5-dioxopyrano [3,4-e]-l,3-oxazine (2a). Other
compounds showed no significant activities. The I.R. and NMR spectral data of the
synthesized compounds were also discussed and are included.