A new spectrophotometric method for the determination of captopril in pharmaceutical preparations

Abstract

extraction of the drug Captopril from capotine (angiotensin converting enzyme
inhibitors (ACE inhibitors) ) with hot water was studied .Reaction of Captopril with
Cu+2 ion was also studied and found to forms a complex [(3 – Mercapto -2- methyl –
propionyl)] – L – proline copper (ІІ) The new analytical method based on measurement
the molecular absorbance in UV-Visible Spectrum at λmax=760 nm. Optimum pH and
divalent copper ion concentration were estimated . Linearity ( 0.50-0.78%) , Detection
limit 0.35% , Relative standard deviation %RSD (2.13) were determined . the complex
is identified with UV-Visible and IR spectra .the mole ratio also investigated and found
1:2 (Cu+2: Captopril).