Spectroscopic, synthesis studies and evaluation of the biological activity of some new-3-(2hydroxy benzylidene) amino)-2-phenyl quinazolin-4(3H)- one Schiff base complexes

Abstract

This research includes the synthesis of a number of new complexes of some transition elements such as Co(II), Ni(II), Cu(II) and non-transition elements Zn(II), Cd(II), Hg(II) with the ligands of Schiff bases resulting from the condensation reaction between Salicylaldehyde and 3-amino-2-phenylquinazolin-4(3H)-one.
The ligand and its complexes were studied and diagnosed through molar electrical conductivity, magnetic susceptibility measurements, electronic spectra, infrared spectra, proton nuclear magnetic resonance spectroscopy, gas chromatography-mass spectrometry, and biological activity of the ligand and some of its complexes has been studied. It was shown through the study that the ligand gives neutral, non-electrolytic complexes that have the chemical formula [M(HBAPQ)Cl2] and [Co(HBAPQ)2)Cl2] as:
M = Ni(II),Cu(II), Zn(II),Cd(II),Hg(II)
HBAPQ = (E)-3-((2-hydroxybenzylidene)amino)-2-Phenylquinazolin-4(3H)-one
The values of the electronic spectra and magnetic susceptibility measurements showed that the prepared complexes were tetracoordinate tetrahedral geometry, except for the cobalt (II) complex, which was hexacoordinate octahedral geometry.
Keywords: transition element complexes, quinazoline Schiff base ligands, quinazolinone complexes