Facile and sensitive Spectrophotometric Determination of Lidocaine in Pharmaceutical preparations and Environmental wastewater samples

Abstract

A rapid, accurate, precise, simple, economical, and sensitive UV spectrophotometric approach was devised to determine the amount of lidocaine present in pharmaceutical preparations and environmental wastewater samples. This approach exhibits maximum absorbance at 265 nm in 0.1MHCl. Beer's law was followed between 0.05 and 0.7mg/ml. The technique's molar absorptivity has been 45 ×104L.mol-1.cm-1, its relative standard deviation has been no more than 1.0%, and its accuracy (avg. recovery percentage) has been 100 ± 1.10. Lidocaine concentrations in pharmaceutical formulations (ointments) and samples of industrial wastewater were successfully determined using this methodology. Precision and sensitivity tests were used to validate the suggested approach, demonstrating its applicability for routine Lidocaine measurement in real samples.