Synthesis of Novel Heterocyclic Compounds via Schiff bases

Abstract

In the present study a series of some four-,five-and seven-membered heterocyclic
compounds have been synthesized by the reaetion of Schiff bases (1a,b) with chloroacetyl
chloride, sodium azide, thioglycolic acid or various anhydrides to give azetidinone (2a,b),
tetrazole (3a,b), thiazolidinone (4a,b) and 1,3-oxazepine derivatives (5-8a,b) respectively.
Schiff bases (1a,b)were prepared from the reaction of p-toluidine with aromatic
aldehydes. All synthesized compounds were characterized by physical properties and spectral
data.
Key words:- Azetidinone, Tetrazole, Thiazolidinone, 1,3-Oxazepine .