Effect of Carbamazepine on Biochemical Parameters in Central Nervous System Patients

Abstract

The response of serum glucose, Acetylcholinesterase, Haemoglobin and Urea
to administration of carbamazepine drug was examined in Trigeminal neuraglia,
Epilepsy, Brain tumour and various cases with short treatment. Carbamazepine in a
dose of 80 mg / day given orally significantly inhibited the activity of AchE in the
serum by (-57.5%) for a period of three years in trigeminal neuralgia patient in
comparison with the control group. Also noted significantly an increased of the level of
glucose by (66.3%) for a period of 12 months in Brain tumour patients. This drug
increased the level of urea but decreased the level of Haemoglobin in Epilepsy
patients.
The results indicate that carbamazepine changes AchE activity and possibly the
central cholinergic neurotransmission.