Level of Serum Complements and Immunoglobulins in Iraqi Insulin Dependent Diabetes Mellitus.

Abstract

Background: Diabetes mellitus (DM) accompanied with increased in the death rate and
represents a significant public health challenge. It is the cause of other disorders and infection in
many body organs. Hence, it is important to study the possible changes in the immunological
components in the serum of diabetic patients which are not well understood. In this work, serum
C3, C4, IgA, IgG, and IgM were estimated in the patients with insulin dependent diabetes mellitus
(IDDM) and compared with healthy persons.
Patients and Methods: Twenty-one insulin dependent diabetic patients in addition to
twenty-four healthy persons as control group were participated in this study. Serum C3, C4, IgA,
IgG, and IgM were measured using immunodiffusion plates.
Results: The results showed a significant increase (p<0.05) in serum C3 and IgA while there
is no significant difference (p>0.05) in the concentration of the complement C4 and serum IgG and
IgM in IDDM patients as compared with healthy control group.
Conclusion: The changes profile of some serum immunological components in IDDM can
be explained in the means of the possible changes in immunity system as an inflammatory response
in DM as a consequence of hyperglycemia. Comprehensive immunological study of all
immunological changes in the IDDM patients is required for a complete explanation.