Synthesis And Characterization Of New 2-amino pyridine Derivatives

Abstract

New series view of ethyl2-(pyridin-2-ylamino) acetate compounds were
synthesized by react 2-amino pyridine with ethyl chloro acetate and KOH, then the
ethyl2-(pyridin-2-ylamino)acetate react with hydrazine hydrate (99%)to give 2-
(pyridin-2-ylamino)acetohydrazide[2], which the 2-(pyridin-2-ylamino)
acetohydrazide treated with different substituted aromatic aldehydes formed various
substituted arylidine derivatives [3a-d]. These arylidine derivatives on treatment with
triethyl amine and chloroacetyl chloride yielded different azetidine derivatives [4ad].
Reaction of 2-aminopyridin with different aromatic aldehyde and CuCN formed
various substituted cyanic [5a-c] .Reaction of [5a-c] compound with NaN3,NH4Cl and
DMF afford tetrazole derivatives [6a-c].Also 2-amino pyridine reacted with 2-
mercaptobenzoxazole,2-mercaptopyrimidin and 2-mercapto benzo thiazole to give the
new derivatives of compounds[7,8,9].The molecular structure were characterized by
FTIR,1HNMR.