Synthesis and antibacterial activity of bis-oxadiazole derivatives

Abstract

New compounds containing two heterocyclic rings (1,2,4 and 1,3,4-
oxadiazole)in the same molecules have been synthesized through many reactions .
Prepared of 1,2,4-oxadiazole derivatives (3) by refluxing the oxime compound (2) and
ethyl p-methyl benzoate with sodium ethoxide for 48 hrs. Synthesized the 1,3,4-
oxadiazole derivatives (7a-l) by reaction prepared hydrazide and many acids with
phosphorus oxychloride (POCl3). All the Synthesized compounds were characterized
by melting points, FTIR and 1H-NMR data. All the final compounds have been
screened in vitro for their antibacterial activities against five types of bacteria [Grampositive(
S. aureus, S. cerevisiae and C. diphtheria) and the Gram-negative(E. coli and
P. aeruginosa)] in two concentration (100 and 200 )μg/mL. The result showed
considerable antibacterial activities against Gram-positive (G+) , but did not show any
antibacterial activities against Gram-negative (G-)