Anti-inflammatory, antinociceptive and antioxidant activities of ethanolic extract of Solanum nigrum L. fruits

Abstract

Ethanolic maceration extract of Solanum nigrum L. fruits belonging to solanaceae
family was used. Anti-inflammatory activity of the extract was examined using
carrageenan induced paw edema and xylene induced ear edema in mice. Antinociceptive
activity was studied using the hot plate and writhing tests. The study was carried out
using doses of 100, 200 and 400 mg/kg orally. The extract showed significant antiinflammatory
and antinociceptive activity at the dose of 400 mg/kg (P < 0.01) as
compared to standard drug Diclofenac sodium (50 mg/kg). Antioxidant and reducing
power activities were evaluated using different concentration (100-400 μg/mL) of
ethanol extract. The extract had the most potent antioxidant effect toward linoleic acid
model system, and strong reducing power ability.