Developing a computer program using Simplex Optimization to determine the preferred method for measuring chromium in biological tissues

Abstract

A computational investigation has been used to chose the best acid which gave the real
concentration of chromium in Certified Reference Material (C.R.M) type (MA-A1) (known
concentration of chromium ) .
A concentration of chromium which obtained from the Atomic Absorption Spectroscopy
(AAS) of (C.R.M) were input using Mathlab Ver.6.1 program and simplex optimization
method .
The program was written and the condition of experiment such as (weight of substance,
type of acid, dilution factor and the response of AAS) were input as a matrix .
In order to reduce the contamination of chromium which come from dust , tow conditions
were input in the program , the first one is the comparison between the real concentration
and the concentration which was obtained from AAS and the second one is to obtain the
smaller concentration of chromium in the substance (C.R.M) .
In this paper the results has been represented by one point on the curve (which is related
to the absolute error as a function of the concentration for each acid ) depend on a such
condition . this curve gave a low absolute error using second order ordinary equation ,
the point showed that the (HClO4:H2O2)(1:1) is the best mixture for chromium analysis. The
computational results showed that its possible to measure concentration of other elements
for different source and hens deferent input conditions depend on such experiment using this new program.