Antioxidant, Antibacterial and Cytotoxicity Activities of Flavonoid Extract From Capsicum annum L. Seeds

الملخص

The present study was designed to determine the antioxidant, antibacterial and
cytotoxicity activities of the flavonoid compound (F1) extracted from Capsicum annum L.
Seeds. The compound showed greater antibacterial activity against gram positive
(Staphylococcus aureus, and Streptococcus aureus) bacteria than gram negative (Klebsiella
pneumonia, Pseudomonas aeruginosa and, E. coli) using the disc diffusion method. The
extract showed high activity against Streptococcus aureus with a zone of inhibition (40 mm)
than that of E. coli (20 mm) at a concentration of 60 mg/ml. Antioxidant, reducing power and
chelating of ferrous ion activities were also significantly higher in the flavonoid compound
(F1). It was found that these activities were increase as the extract concentration increases
(using three concentration 15 mg/ml, 30 mg/ml & 60 mg/ml, respectively). The results
showed that the flavonoid compound F1 had no cytotoxicity against the human red blood cells
in all the concentration tested (ranging between 0.5-200 ppm), by using DMSO solution as a
control.