Evaluation of Serum Cholinesterase Activity, Lipid Peroxidation and Lipids Profile in Type 2 Diabetes Mellitus

الملخص

The study was designed to evaluate serum cholinesterase activity, lipid peroxidation,
lipids profile and nitric oxide production, in sera of diabetes type 2 and the control group to
show whether there are changes in their levels.
The results of this study showed significant elevations (P< 0.001) in each of serum
cholinesterase and lipid peroxidation end product represented by serum MDA concentrations in
type 2 diabetic patients as compared to control group.
Although, this study showed a non-significant elevation in serum nitrite, the nitrate was
elevated significantly (P< 0.001) in diabetic type 2 patients as compared to control group. The
lipids profile of diabetic type 2 patients showed significant changes represented by significant
elevations (P< 0.001) in each of TG, t. cholesterol, LDL and VLDL, and a significant decrease
(P< 0.001) in HDL as compared to control group.
Using regression analysis showed a significant positive correlation between serum
cholinesterase (P< 0.001) and each of FBS (r = 0.698), MDA (r = 0.69), NOx (r = 0.51), t.
cholesterol (r = 0.487), TG (r = 0.691), LDL (r = 0.575), and VLDL (r = 0.455), and a
significant negative correlation(P< 0.001) with HDL (r = - 0.861).
Conclusion can be made that diabetes mellitus is a low grade systematic inflammation
associated with high oxidative stress, lipid peroxidation and serum cholinesterase activity,
which may in turn, affect lipoproteins metabolism.