Synthesis of New Derivatives of N- Substituted Saccharin Via Glycine Derivatives.

الملخص

The present work include the synthesis of N – α- saccharylbenzyl-Nphenylglycine
and its derivatives were achieved which expected to have some
biological activity. The first step was the treatment of primery aromatic amine with
primery aromatic aldehyde in boling ethanol to give Schiff's bases , which is
converted to N- α- chlorobenzyl-N-phenylglycine by its reaction with chloroacetic
acid in dry benzene. The synthesized glycine derivatives were reacted with saccharine
to give N – α- saccharylbenzyl-N-phenylglycine. The new prepared compounds were
identified by physical properties and UV/Vis., IR and 1HNMR spectrum.