Synthesis and Identification of some heterocyclic derivatives from carboxylic acid

الملخص

This research involved heterocyclic compounds such as (β-lactam ,oxazepine Thiazolidine -4- one , imidazolidin -4-one) derivatives , where prepared frome oxaliodihydrazide(1) which was prepared previously from oxalic acid.
(1) is reaction with 4-amino acetophenone to get shiff base derivatives (2),which reaction with Vanillin to yeild shiff base (3) .
(3) reaction with (Chloroacetyl chloride, thioglycolic acid ,phthalic anhydride , malic anhydride , succinic anhydride , glycine , alanine,tyrosine , phenylalanine) to get as [β-lactam derivatives(4) , Thiazolidine -4- one derivatives (5) , oxazepine derivatives(6), (7) and(8), imidazolidin -4-one derivatives(9) ,(10),(11) and((12) ].

All this compounds characterized by means of FT- IR ,and some of the compoundes by means 1H-NMR,and 13C-NMR,C.H.N, and follow reaction by Rf - TLC and Measure ment melting point .