Comparative Study for Antibacterial Activity of Some Maleamic acid Derivatives with Some Commercial Antibiotic
الكلمات المفتاحية:
Maleamic acid derivatives، antibacterial activity، ampicillin، gentamicin، tetracyclineالملخص
Antibacterial activity of the following prepared compounds: Bis-Maleamic
acid, Ethylene-Bis-Maleamic acid, 1,4-phenylene [2,2-diamino-Bis (1,3,4-thiadiazol-
5-yl)] Maleamic acid, 4-N(2,3-dimethyl-1-phenyl pyrazolin-5-one-4-yl) Maleamic
acid and 5-methyl-3-sulfanilamido Maleamic acid-isoxazde (Maleamic acid
derivatives) were tested against five pathogenic bacterial species. These
werePseudomonasaeruginosa, Escherichiacoli, Salmonellatyphimurium,
Proteusmirabilis (Gram negative) and Staphylococcusaureus (Gram positive). Results
showed that all tested compounds have good antibacterial activities comparing with
antibiotics Ampicillin, Gentamicin and Tetracycline. The highest growth inhibition
zone diameter for the compounds were (30 mm) against S. aureus and P. aeruginosa,
(28 mm) against E. coli, (23 mm) against S. typhimurium and (14 mm) against P.
mirabilis.
