Synthesis of Prodrug Ciprofloxacin Procain Male amide Polymer

الملخص

In this research, two new drugs were bonded through amide attachment using Maleic
acid as aspacer binder ,produced di prodrug such as Procain and Ciprofloxacin.
SinceProcain has localanesthetic action.and Ciprofloxacin as antibacterial drug was
reacted with Maleicanhydride and free Procain oil produced amide attachment, the NProcainMaleamic
acid (1) was converted to its acyl chloride by using thionyl chloride (2)
then reacted with ciprofloxacin to obtain amide bond as a new prodrug (3), then
polymerized free radically to obtain prodrug polymer(4) which was studied by controlled
drug release in different pH values at 37C˚ ,to improve their characteristic and to
minimize the side effect of the drug to be broad spectrum activity as atherapeutic
material.This mutual prodrug was used with another biological active drug instead of
single action. The prepared prodrug polymer(4) was characterized by FTIR , 1H-NMR
,and UV spectroscopies ,the physical properties were determined was measured .The
good results were obtained as sustained release of ciprofloxacin with broad spectrum antibioticbiological assay were conducted for prepared prodrug polymer using. The
prepared prodrug showed high biological activity against E.coli, staphylococcus aureus
and pseudomonas acuroginosoma.The prepared prodrug appear high biological activity,
compared with standard Gentamycin.
Keywords: Maleamic acid, Ciprofloxacin, Procaine, prodrug