The Protective Effect of Quercetin on Diazinon-Induced Oxidative Stress in Rats

Abstract

The aim of this study is to evaluate the protective effect of quercetin on diazinoninduced
oxidative stress in the liver, kidney and heart tissues of male albino rats. The
current study included 24 male rats, which were divided into 4 groups, each group
included 6 rats: group 1 as a control group ,Group 2 was given diazinon at 10 mg/kg
/day, orally via gavage ,Group 3 was given quercetin as intraperitoneal (IP) at 25
mg/kg/day and diazinon + quercetin group were given diazinon at 10 mg/kg/day/orally
via gavage and quercetin at 25 mg/kg/day, IP for 4 weeks. The results show significantly
increase in serum ( AST and ALT activity),(urea and creatinine levels) and (Creatine
kinase activity) which is associated with histopathological damage of the liver, kidney
and heart tissue's architecture respectively due to the administration of the diazinon and
this increase or damage is positively correlate with concentrations of the liver, kidney
and heart MDA and negative correlation with the activity of catalase, superoxide
dismutase and glutathione peroxidase on the liver, kidney and heart tissue homogenate,
this modulation of the biological parameter histological damage is significantly
neutralized by the administration of the quercetin. Our data suggest that supplementation
of quercetin may be useful in reducing diazinon hepatotoxicity, nephrotoxicity and
cardiotoxicity in rats which has the potential protective effect of quercetin and can be
said.