Preparation, Characterization of Acid Hydrazide Schiff Base Complexes of Nickel (II) and Their Biological Activity

Abstract

The work reported in this research deals with the preparation,characterization and
biological studiesofhomodinuclearNi(II)complexeswith three Schiff base
ligands. The ligands are: dibenzoinlidenemalonoyldihydrazide (BMDH4),dibenzoinlidenesuccinyldihydrazide(
BSDH4)and dibenzoinlidenephthalolyldihydrazide(BPDH4)
which areobtained by the reaction ofmalonoyldihydrazide ,succinyldihydrazide and
phthalolyldihydrazide with benzoin in mole ratio1: 2.The preparation of the complexes
was carried out in both neutral and basic media and have beencharacterizedphysico-
chemically and they found to have the formulas [Ni2(LH4)2]X4 in neutral medium
and [Ni2L2]in basic mediumrespectively.Octahededralstructure has beensuggested for
all thehexacoordinatedcomplexes .Furthermore the complexeshave been found to be
biologically active as demonstrated by antibacterial screening against four human
pathogenic bacterial stains. It has been found that thecomplexes were more
effective agent than the ligands(where X=Cl-,NO3
- ).