Kinetic and Thermodynamic Investigations of the Reaction between Metoclopramide Hydrochloride and para- Dimethylaminobenzaldehyde

Abstract

Kinetic study of the condensation reaction of metoclopramide drug with paradimethylaminobenzaldehyde
(DAB) in weakly acidic EtOH/H2O has been investigated.
A reversible first order reaction with respect to DAB and zero order with respect to
metoclopramide has been observed. The rate constants, activation energies, preexponential
factors, and other related thermodynamic functions of activation for both
forward and reverse reactions have been determined. Standard thermodynamic
parameters including equilibrium constant, ΔGo, ΔHo, and ΔSo have been calculated.