Synthesis and Characterization Of Some New Heterocyclic Compounds Such As: Oxadiazole and Azetidine-2-One Derivatives

Abstract

A series of four membered ring the azetidine-2-one 3(a-c) have been synthesized via
Schiff bases 2(a-e) with derivative of acetic acid in the presence of triethylamine with
phosphorusoxychloride using dry methylene chloride under inert nitrogen atmosphere at 0 °C.
to furnish the corresponding azetidine-2-one 3(a-c) in moderate yields.on the other hand
aseries of five membered ring synthesized Substituted 1,3,4-oxadiazoles are of considerable
pharmaceutical and material interest by treatment of a suspension of methyl salicyliate
hydrazide (1) in ethanol reflux with hydrazine to give 2-hydroxybenzohydrazide (2) this
compound treated with Carbon disulfide(CS2) in the presence of sodium hydroxide to give 2-
mercapto-1,3,4,-Oxadiazole (3)this compound treated with hydrazine in ethanol to give 5-
hydrazino-1,3,4-Oxadiazole(4). Finally treatment of (4) with 2-bromobenzaldehyde to gave
1,3,4—Oxadiazole derivateives The structural of these compounds were monitored and
confirmed by using spectroscopic tools as IR and 1HNMR spectra Elemental analysis.