Synthesis of [ N-Ampicilline Amic acids]as Drug Polymers

Abstract

In this paper two monomers have been prepared such as [N-Ampicilline male amic acid
M1, and N-Ampicilline citraconic amic acid M2] , from reaction of ampicillin with maleic
anhydride or citraconic anhydride at room temperature using dioxane as a solvent.
The two new prepared monomers M1andM2 were polymerized by free radical with
Azobisisobutyronitrile (AIBN) to their corresponding poly amic acids P1 and P2. Which
were converted to their sodium salt polymers P3 and P4 to enhanced their solubility in water.
The physical and chemical properties were studied, the prepared monomers and polymers
were characterized by FTIR and UV. spectroscopy, the intrinsic viscosity was measured
Ostwald viscometer at 30 0C with DMF as a solvent, the swelling % was calculated and the
drug release rate was studied. Experimental results showed that the hydrolysis of ampicilline
in alkaline medium was higher than acidic medium.
TG and DTA and DSC Analysis were studied for P1 and P2.