Effect of Some Heterocyclic Compounds on Human Serum AChE

Abstract

This study is designed to show the effect of fifteen heterocyclic compounds
on the activity of AChE in sera, all compounds showed strong inhibition
ranging between (80.3 %-93.7%) at concentration up to 1x 10-2 M.it was
found that the percentage of inhibition is increased with the increase of
concentration of inhibitors and 3-phenyl-6-[5'nito-2'-furyl)ethyl]-1,2,4-
triazole[3,4,6], [1,3,4] thiodiazole (9) was the most effective inhibitors.
Kinetic properties of these inhibitors are studied and Lineweaver-Burk plots
were nused to determine the type of inhibition, all studied compounds
behaved as non-competitive inhibitors. The mechanism of action of
heterocyclic compounds as inhibitor to serum AChE activity was suggested