Synthesis of new flavanones from polyhydric chalcones Badie Ali Ahmed and Heba Amin Ibrahim

Abstract

This work is concerned with the synthesis of α, β_unsaturated carbonyl
compounds namly chalcones (1-10), through condensation of 2,5_dihydroxy
acetophenone with different homo and hetero aromatic aldehydes under basic
medium. These chalcones are used as synthones in synthesizing the target flavanones
(11-20), via cyclization reaction using sodium hydroxide or sulfuric acid in absolute
ethanol.