Copper and zinc levels in sera and tissue of patients with lymphoma and the effect of storage solution and the time on tissue content of Cu and Zn

Abstract

Copper and zinc concentration were measured in 14 patients with
malignant lymphoma and 18 with benign tumors,higher levels of copper (154.2
±36.7), (20.2 ±4.2)in sera and tissues respectively in patients having lymphoma when
compared with those of benign tumors .estimation of zinc metals showed no
significant decrease in sera of lymphoma patients but higher concentration
(34.45±11.73) in tissues of them when compared with respect of benign tumors .
The storing effect on copper and zinc concentration in tissue samples
which were stored in both storage solution (normal saline and formalin ) were also
studied .It was found that the copper concentration levels could be measured in tissue
which was stored in normal saline up to fife days in benign tissues and up to three
days in malignant tissues , and up to four days in benign tissues and up to seven days
in malignant tissues for zinc determination .Using formalin as a storage solution ,
copper could be measured in tissue which was stored in formalin up to fife days in
benign tissues and up to eight days in malignant tissues , and up to fife days in benign
tissues and up to seven days in malignant tissues for zinc determination.