Biological Activity of The Complexes of Hg(II), Zn(II) and Cd(II) Mixed Ligands (Thiosemicarbazone and Azine) part II

Abstract

The biological activity of the two ligands (benzaldehydethiosemicarbazone-
BTSCH and 3,4–dimethoxybenzaldazine- DMBA) and their zinc(II)-, cadmium(II)-
and mercury(II)- complexes having the formula M2(BTSCH)2(DMBA)2X4 and
M(BTSC)(DMBA)X (where BTSC=deprotonated BTSCH ligand; M = Zn2+, Cd2+, or
Hg2+; X = NO3
- or Cl- or I-) in dimethylsulphoxide solution have been evaluated by
agar plate diffution technique against five human pathogenic bacterial strains:
Staphylococcus aureus, Bacillus subtilis, Klebsella pneumonia, Escherichia coli and
Proteus vulgaris. The ligands had no activity, whereas some of the complexes were
found to have antibacterial activity on some bacteria in vitro, The effective
concentration of the complexes ranging between 0.01 - 10 μg/ml.