The Antimicrobial Activity (Antibacterial, Antifungual) Of Some New 3-Substituted Isobenzofuran-1(3H)-One Derivatives

Abstract

In this research a new series of 3-(substituted) isobenzohuran-1(3H)-one(B,D)
and O-benzoyl benzamide derivatives (C,E) were studied successfully . The synthesis
of these compounds has been described in the scheme 1. These products were
screened for antifungal, antibacterial and enotoxic effect. It was found that all tested
compounds have antifungal activity. Compound A1,A2,B2 and C3 were found to be
active against Escherichia coli ,Bacillus subtilis and Staphylococcus aureus
.Genotoxic effects using Ames test showed chart compound A1 and A2 have a weak
base-pair substitution mutagenicity while a clear base- pair substitution mutagenic
activity was shown by B4. Using TA100-strain of salmonella typhimurium compound
D showed a framshift mutagenicity while a weak oxidative mutagenic action was
revealed by compound E no change on the mutagenicty of the tested chemicals was
observed after using the S9 metabolic action system.
(Hint: all of the organic compounds were prepared according to references [19].