The Correlation between Glutathione Peroxidase Activity and Diene Hydroperoxide Level in Serum of Patients with Diabetes Mellitus Type II

Abstract

The present study was designed to evaluate the oxidative stress-related parameters in
sera of diabetic patients and healthy control . Some of the enzymatic and nonenzymatic
factors were measured in sera of diabetic comparing with control groups.
The results show that glutathione peroxidase activity and the levels of Vitamin E
significantly decreased, while CDH levels increased in sera of patients (male and
female).These data suggest that hyperglycemia induces oxidative stress in sera of
patients compared with healthy controls and that antioxidants which used in the study
are effective against oxidative injury.
Key word:- ROS:Reactive Oxygen Species ,CDH: Conjugated Diene Hydroperoxide,
GSH; reduced glutathione, GSSG; oxidized glutathione, GRD; glutathione reducates,
GPX; glutathione peroxidase,AR; aldose reductase.